SIFT predicts whether an amino acid substitution affects protein function based on sequence homology and the physical properties of amino acids. SIFT can be applied to naturally occurring nonsynonymous polymorphisms and laboratory-induced missense mutations.

UPDATE on 25 Apr 2024
  • Security updates
UPDATE on 31 Mar 2022
  • Move to new server
UPDATE on 6 Dec 2019
  • Change SIFT4G Annotator to browse for genome locally instead of dynamically querying SIFT website due to change in A-STAR security web policy
  • Github code for building SIFT 4G databases changed to allow more per missive gff files (start and stop codons no longer required)
UPDATE on 17 July 2019
  • Added security to the webpages SIFT Sequence, SIFT Related Sequence, and SIFT Aligned Sequences
UPDATE on 20 March 2018
  • Added field validation to the webpages SIFT For Genomes and SIFT indels
UPDATE on 18 March 2018
  • Added field validation to the webpages SIFT Sequence, SIFT Related Sequence, and SIFT Aligned Sequences
UPDATE on 14 March 2018
  • Removed SIFT BLink website
UPDATE on 25 July 2017
  • Back-end maintenance for mail server issues
  • SIFT For Genomes changes on github
UPDATE on 3 March 2017
  • Reorganize website integrating SIFT 4G webpages with SIFT.
Genome Tools Single Protein Tools
SNV / SNP prediction

SIFT 4GSIFT For Genomes Predictions for human build 37, 38, and > 200 genomes 		protein sequence toolSIFT Sequence
      SIFT For Genomes (Online submission) (Beta) Predictions for some model organisms (e.g. human, mouse, worm, yeast). protein homologues toolSIFT Related Sequence
      dbSNP rsIDs (SIFT4G predictions) protein aligned sequences toolSIFT Aligned Sequences
INDEL Prediction
1. genome coding variants filter tool Restrict indels to coding
 2. Classify coding indels (Insertion/Deletions). Human build 37 and 38)